CLINICAL COHORTS

Hospitals

Individuals

Cases found

The information is updated on a regular basis*

WHY ARE WE DOING THEM?

To evaluate the association between circulating SARS-CoV-2 variants and the risk of developing short, mid and long-term clinical outcomes. To this end, we establish and study two cohort registries of patients (>18 years) hospitalised with COVID-19 and/or with long-term sequelae of COVID-19 symptoms after the acute infection. The studies are carried out across Europe, Africa, Asia and America, pooling prospective as well as retrospective information from healthcare centres and existing cohorts.

To evaluate potential reduction in real-world vaccine efficacy due to circulating SARS-CoV-2 variants different from the original Wuhan strain. To this end, we will establish and evaluate a cohort of health care workers across Europe, which together with the cohort of hospitalised patients provides the needed prospective as well as retrospective information.

OBJECTIVE(S) OF THE CLINICAL STUDIES

Primary aims

• To evaluate the association between circulating SARS-CoV-2 variants and risk of in hospital death during the acute phase of the disease. Sub-aim: To decompose the total effect of circulating SARS-CoV 2 variants on risk of death in direct effect and indirect effect via hospital re-organisation, pharmaceutical and respiratory support interventions.

• To evaluate the association between circulating SARS-CoV-2 variants and risk of post-acute sequelae SARS-CoV-2 conditions (PASC) Sub-aim: To decompose the total effect of circulating SARS CoV-2 variants on risk of neurological PASC in direct effect and indirect effect via respiratory support interventions.

• To evaluate the potential reduction in real-world efficacy of vaccine efficacy attributable to SARS-CoV-2 circulating variants.

Secondary aims

• To evaluate the long-term outcome according to variants or specific mutations
• To evaluate long-term residual organ damage (lung, hearth, CNS, PNS) in relation to patient’s characteristics and virology (variant, specific mutations, viral load in the acute phase)
• To evaluate the impact of vaccine hesitancy on the distribution of variants

CLINICAL SITES

Country	Hospitals	Patients Cohort	HCW Cohort	Long COVID-19 Patients Cohort
KE	KEMRI Alupe Hospital	x
MX	Juan Graham Casasus Regional Hospital	x	x	x
PL	Pomeranian Medical University	x
SE	Karolinska Institutet	x
PT	Centro Hospitalar De Lisboa Ocidental	x	x	x
DE	Heinrich-Heine-Universität Düsseldorf	x		x
IT	ASST Santi Paolo e Carlo	x	x	x
UK	Imperial College Of Science Technology And Medicine	x		x
LT	Viesoji Istaiga Vilniaus Universiteto Ligonine Santaros Klinikos	x	x	x
BR	Federal University of Minas Gerais	x	x	x
IT	Universita degli studi di Roma Tor Vergata	x	x	x
IT	IEO		x