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New paper published on the “Rapid selection of Sotrovimab escape variants in SARS-CoV-2 omicron infected immunocompromised patients”

Prolonged viral shedding of SARS-CoV-2 Omicron variants (BA.1 and BA.2) was observed in a cohort of immunodeficient patients after treatment with the monoclonal antibody sotrovimab. This was associated with rapid selection of escape mutations, the relevance of which was confirmed in a pseudovirus neutralization assay. However, selection of sotrovimab resistance–associated mutations was significantly reduced by combination therapy with remdesivir.

5 thoughts on “New paper published on the “Rapid selection of Sotrovimab escape variants in SARS-CoV-2 omicron infected immunocompromised patients””

  1. Yes and… What do you do when you just can’t convince the parents that play based learning is meaningful. I teach Pre-K. Every year I have parents who are anxious and adamant that their child should be having daily reading instruction. I think this is poppycock but I’m not reaching them when I explain the importance of play. ☹️

  2. What I’m saying is play-based learning isn’t ‘teaching kids through play’. It’s recognising that play alone IS learning, we don’t have to do anything to it. Yes, kids can learn through teaching too. So just call it that, teaching.

  3. As an unschooler I think children are perfectly capable of educating themselves and don’t see a need for adult-led ‘play’ or learning unless it is requested. Adults play an important role of course but to me it’s more of a support/help/facilitator role, not teacher or leader.

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